The rapidly changing climate puts commonly used crop plants under strong pressure. Furthermore, restrictive legislation inhibits the use of GMOs and gene editing thus strongly limiting current breeding technologies.

epibreed AG has developed TEgenesis, a patented method to rapidly improve crops to better withstand stresses and to acquire novel traits of interest by taking advantage of their natural adaptive potential. TEgenesis is applicable to virtually any crop.

We have developed TEgenesis, a novel breeding technology that takes advantage of directed evolution. The method is based on the combined drugs and stress-induced mobilisation of endogenous transposable elements (TEs). TEs are naturally occurring powerful endogenous segments of the plant genome that have the capability to amplify themselves, change location within the genome and to rewire complete gene regulatory pathways. Therefore, a TE responding to a specific stress can create novel pathways that respond to the same stress. This can be an advantage for the plant since it can result in stable and heritable resistance to that stress very rapidly.

Our newly developed and patented TEgenesis treatment for plants for the first time unlocks the use of TEs for breeding in virtually any crop.

TEgenesis: How it works. A. Original crop plant and one of its chromosomes represented below (light grey) containing one TE insertion (black triangle). B. The original crop does not withstand strong stresses because it only contains one gene responding to that (red arrow). C. Novel crop variety generated by the TEgenesis and stress-mediated mobilisation of TEs (additional black triangles on the chromosome). D. The generated crop variety is better adapted to the stress because it has evolved several novel genes capable of responding to that stress (red arrows).

© by epibreed AG for all contents and images